What is ZubSolv?

Marketed like buprenorphine, for maintenance. What's the difference? (Zubsolv vs bupe?)

Buprenorphine is a "partial agonist" for opiates and opioids, which means it competes with opiates and opioids for the brain receptors that are activated by those drugs. It is also a "partial antagonist" for those same addictive drugs, for other receptors. Partial agonists (and agonists, and antagonists) are sometimes used to prevent the highs that come from drug abuse (by interfering with the drug).

(08 Jan '14, 15:15) admin ♦♦


Addiction Treatment

Buprenorphine (and other mu-opioid receptor antagonists) is used for addiction treatment via maintenance programs (like methadone maintenance programs)


Opiate Addiction

Opioid (and opiate) addiction is difficult to treat. In some cases, addicts are transferred away from illegal opiates and opioids, and started on legal, allegedly less-problematic drugs like Buprenorphine (and ZubSolv).



Opioids are highly-addicting substances, acting on brain receptor sites in ways known to be directly associated with compulsive behaviors (like drug addiction).



ZubSolv is a formulation that includes Buprenorphine.

ZubSolv is a formulation of Buprenorphine and Naloxone, from Orexo US pharmaceutical company. It is marketed as an alternative to Buprenorphine, for opiate addiction maintenance programs (opiate addiction treatment by substitution).

Orexo markets ZubSolv as better than generic bupremorphine because it dissolves faster than typical sublingual buprenorphine tablets.

Many addiction treatment professionals work hard to treat opiate addiction without reverting to substitution (maintenance), because opiate maintenance programs (like thise using ZubSolv) do not treat the underlying causes of drug abuse nor do they treat the compulsive behavior associated with the addiction.

Orexo's marketing materials recognize this fact:

ZUBSOLV® (buprenorphine and naloxone) sublingual tablet (CIII) is a prescription medicine used to treat adults who are addicted to opioid drugs (either prescription or illegal) as part of a complete treatment program that also includes counseling and behavioral therapy.


answered 08 Jan '14, 15:30

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Thanks that was fast! I also found the Orexo list of cautions about ZubSolv, which includes some serious issues everyone should know about:

Keep ZUBSOLV in a secure place away from children. If a child accidentally takes ZUBSOLV, this is a medical emergency and can result in death. Get emergency help right away

ZUBSOLV can cause serious and life-threatening breathing problems. Call your doctor right away or get emergency help if (a) you feel faint, dizzy, or confused; (b) your breathing gets much slower than is normal for you; (c) you feel sleepy and uncoordinated; (d) you have blurred vision; (e) you have slurred speech; (f) you cannot think well or clearly; or (g) you have slowed reflexes and breathing. In an emergency, have family members tell the emergency department staff that you are physically dependent on an opioid and are being treated with ZUBSOLV

The most common side effects of ZUBSOLV include: headache, drug withdrawal syndrome, nausea, decrease in sleep (insomnia), vomiting, pain, increased sweating, swelling of the extremities, and constipation. Tell your doctor about any side effect that bothers you or that does not go away

Do not switch from ZUBSOLV to other medicines that contain buprenorphine without talking with your doctor. The amount of buprenorphine in a dose of ZUBSOLV is not the same as the amount of buprenorphine in other medicines that contain buprenorphine. Your doctor will prescribe a starting dose of buprenorphine that may be different than other buprenorphine-containing medicines you may have been taking

ZUBSOLV contains an opioid that can cause physical dependence. Do not stop taking ZUBSOLV without talking to your doctor. You could become sick with uncomfortable withdrawal signs and symptoms because your body has become used to this medicine. Physical dependence is not the same as drug addiction. ZUBSOLV is not for occasional or "as needed" use

An overdose, and even death, can happen if you take benzodiazepines, sedatives, tranquilizers, or alcohol while using ZUBSOLV. Ask your doctor what you should do if you are taking one of these. You should not drink alcohol while taking ZUBSOLV, as this can lead to loss of consciousness or even death

Do not inject ("shoot-up") ZUBSOLV. Injecting ZUBSOLV may cause life-threatening infections and other serious health problems. Injecting ZUBSOLV may cause serious withdrawal symptoms such as pain, cramps, vomiting, diarrhea, anxiety, sleep problems, and cravings

Before taking ZUBSOLV, tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

Before taking ZUBSOLV, tell your doctor if you are pregnant or plan to become pregnant. It is not known if ZUBSOLV will harm your unborn baby. If you take ZUBSOLV while pregnant, your baby may have symptoms of withdrawal at birth. Talk to your doctor if you are pregnant or plan to become pregnant

Before taking ZUBSOLV, tell your doctor if you are breastfeeding or plan to breastfeed. ZUBSOLV can pass into your breast milk and may harm the baby. Talk to your doctor about the best way to feed your baby if you take ZUBSOLV. Monitor your baby for increased sleepiness and breathing problems

Do not drive, operate heavy machinery, or perform any other dangerous activities until you know how ZUBSOLV affects you. Buprenorphine can cause drowsiness and slow reaction times. This may happen more often in the first few weeks of treatment when your dose is being changed, but can also happen if you drink alcohol or take other sedative drugs when you take ZUBSOLV

ZUBSOLV is a controlled substance (CIII) because it contains buprenorphine, which can be a target for people who abuse prescription medicines or street drugs. Keep your ZUBSOLV in a safe place to protect it from theft. Never give your ZUBSOLV to anyone else; it can cause death or harm them. Selling or giving away this medicine is against the law

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Asked: 08 Jan '14, 15:11

Seen: 10,511 times

Last updated: 08 Jan '14, 16:34